Samphire Neuroscience Reviews 95

I'm on my fifth cycle of using Nettle and can honestly say it has made my luteal phase SO much easier. I was sceptical when I ordered the device and half-hoped it wouldn't work so I could get my money back – but it does work, and for me it has been well worth the money so far.

When it first arrived I found it difficult to get the sponges to connect. It still takes me two attempts to get the device fully connected, but it's pretty easy once you get used to it.

In terms of actual impact, before using Nettle I suffered from irritability, depression, fatigue and food cravings throughout luteal. During the first month of using Nettle, these symptoms were still present, but I began to see significant reductions in months 2 and 3. Now I only record 'mild' versions of these symptoms, and they occur much less frequently – around 1–4 days a month, versus 10 days a month prior to Nettle. I would estimate that my mental symptoms have decreased by 75%. This has made me feel more stable, has greatly benefited my relationships and has generally made it possible for me to go about life normally. It's honestly been amazing!

One caveat: I have a copper coil, so I experience bad cramps during my period. Nettle has reduced this pain, but only slightly – I would say it's more like a 25% reduction. I see the device has reduced pain for lots of other people, so I wonder if my situation is different because of the coil.

An interesting thing I've noticed is that when I use the device for 3 days of my period, it makes my period much lighter and shorter! I'm pretty happy with this side effect because the coil made my periods longer and heavier.

Overall, I would highly recommend Nettle to anyone suffering similar symptoms to me. I use it for two weeks every month, from around day 17 to around day 3. I'm so grateful to Samphire for paving the way in this under-researched area. I really hope they manage to get Nettle devices on the NHS to increase accessibility!

I have the Lutea. The app is immensely frustrating. I received the free subscription, I have a login and password but it keeps looping me back to pay for a subscription. Infuriating given that I just have these people close to $600 for something I cannot use because of a $60/month app. Hopefully it would be this difficult getting a refund!

Finally something that works. PMDD and endometriosis has been hell for years. Nettle has definitely reduced severity of symptoms. Worth it.

The headband is very easy to use and you can go about your day with it on. It's a little tickly at first but you get used to it. I've got pmdd and it's too early to tell if it's affecting my mood symptoms but I also have painful periods and cramps and I can't believe how much it's reduced my pain. Almost non existent pain now and the difference is crazy.

I have PMDD and my Lutea (Nettle) has been helping regulate my moods and energy levels.
Two months in and noticing a big difference.

This headband is a game changer. The example I’ll give, which most women with PMDD can relate to, is the feeling of being out of control of your emotions when tangled in a perceived conflict with your partner. These moments can get really intense, really fast, and one such situation presented itself in my first cycle using Lutea. I put the headband on and did a session when I was ruminating post conflict….and wow…within maybe 5 minutes I could see with such clarity what the miscommunication was, my role in it, and that it was in fact a storm in a teacup - that I was wasn’t seeing things clearly - and from that session I had regained my composure and agency to approach my partner with a whole heart and make things right. This was huge, and my first cycle was a lot less stressful than normal. I felt connected to my husband as a result. Mood regulation is so much better. I’m day 22 of the next cycle and started using the band yesterday at day 21 when things start to wobble. So far, so good. I love my Lutea!!

I work in women’s and mental health and using nettle has had the most significant impact on my PMDD related depression out of all other interventions I have tried. It is now something I recommend to clients. The team are always very responsive with any queries.

Nettle really helps me every month, and even knowing it's there as a tool for me makes a big difference. Sessions lift my mood and help me feel more in control of my mood and emotions. I've had it since September 25. The customer service is brilliant and I truly believe Samphire will be everywhere in 5 years, changing the game for even more women

Nettle helps me with my PMDS symptoms and makes everyday life much easier. Before Nettle, I was taking SSRIs, and on really bad days I would occasionally need a calming medication. Overall, I feel like I can control my emotions a little better now. There are fewer extremely bad days.
I use Nettle from ovulation until my period, so for quite a lot of days each month. At the beginning, I had an issue with the device, but the support team was very quick and truly excellent. I received a replacement right away and got immediate help.
Thank you for this wonderful invention! Nettle doesn’t cure my PMDS, but even the fact that it helps a little brings me so much relief. Thank you!

The Nettle has been life changing as someone with pcos and pmdd, and long term depression. It’s helped me to manage my mood and reduced my pain symptoms. It’s not like any other treatment I have experienced, with almost immediate lessening of my anxiety. After 9 months of use, I swear by it. It makes bad days much brighter and more manageable. I am so grateful to be able to experience this after years of struggling deeply. Thanks to the whole team. Great customer service too!

I've been using Nettle since May 2025, and it's given me real, felt relief from some of the psychological symptoms of my PMDD including anxiety, overwhelm, panic. The team is also amazingly responsive to questions/queries/feedback

Less crying, less snapping, just in general a more calm time before my periods. Between loosing weight and pre-menopause, my cycle has become notable longer than it used to be, and I'm so grateful that I don't have to spend that time waiting for my period and the calmer, more positive part of my cycle to begin. Or dreading the luteal phase, when my mood would start to dive.

I found Nettle on a Reddit page. Someone had mentioned a medical trial for PMDD and I was desperate. I was spending half of my month, every month unable to function as a human. I play several sports that require concentration to put it mildly, and I was actually refusing to do them for half of the month because it would end in screaming, tears or suicidal thoughts. I had really got to the end of my tether! I knew the doctors were going to be less than helpful, I didn't want to go down the SSRI or contraceptive route and had already been told a firm no on any permanent surgical solutions.

Nettle has somewhat changed my life! I was sceptical at first, the reviews almost seemed too good to be true but after 3 months (the first two believing it wasn't going to work and it was all a big lie) the changes have been nothing short of a miracle. I still have the odd day where I feel down or angry/irritable, but I am able to acknowledge this and walk away from the situation and start again. I now forget that I have booked competitions and leisure activities on my 'bad' days as they don't cause an issue.

Subsequently, after the medical trial I bought myself my own device and I haven't looked back since. If anyone is looking for an alternative that doesn't include years of being passed around doctor to doctor, just do it! With a money back trial too, what is there to lose in my opinion.

This is my first month using Nettle and already this cycle my luteal phase has been completely different. My PMDD Symptoms are practically nonexistent and hopefully it will help with endo pain as well. Will update to share results. I am amazed with Nettle!

I’ve been using Nettle since it launched and it’s made such a noticeable difference in my pms and pmdd symptoms. I used to have at least 2-3 days every month where I couldn’t function, either due to complete exhaustion, fatigue and anxiety or period pain in the first day of my cycle. With Nettle my body feels much more comfortable overall. My energy levels are sustained, I’m feeling more in control emotionally (not 100%) and the cramping is so much milder that I do not feel I need to take a pain killer anymore or lay down for a nap. Using Nettle allows me to feel more normal during my period and not to miss out on life.

The Nettle from Samphire has been a great addition to my PMDD protocol, I was one of the first batches and the customer service from the founder and her team was quick and efficient. As one of the first batches I got a lemon and it was dealt with quickly. I used it for months consistently and noticed a mood improvement which is such small statement but profound when PMDD disables your normal life. supporting a women led company is always a plus

This company truly cares about women's health. Communication has been excellent from pre-purchase to support afterwards as a US customer. I've been using Nettle for 5 months now. Usually I have a sharp transition from ovulation to luteal phase with a drop in mood and onset of physical symptoms with almost 2 weeks of challenging days. While I haven't noticed a dramatic difference, I feel like I now have one to two days back per month and a smoother transition, which is actually a big deal. More importantly, just having another tool in my toolbelt and knowing research is being done on PMS and PMDD feels so good. I almost cried the first time I needed support on a rough day and found a category of luteal phase meditation on the Samphire app. I felt so SEEN.

A few things I wish I knew- as a US customer I needed an adapter for Nettle (but I purchased before the US version as available so that might be why). There is a subscription for the app, and you will need to get refills for sponges every 3 months or so but they are free or affordable if you go through them more quickly. Pro tip- run a session after you've washed your hair, it's much easier to get a strong connection!

I have been using Nettle for 4-6 months and I feel very happy with it. I don’t know yet if it’s helping my mood, reactivity, lability, etc., yet! I know that I don’t mind the relaxing and mindful time I get 5 times a month after I shower. I have enjoyed and learned a lot from Emilé’s talks on pms and pmdd. Thank you Nettle and excited to keep trying. The app is good too.

First of all, there is an incredible team behind Nettle — genuinely caring, responsive, and always willing to help. Every question I had was answered with clarity, understanding, and kindness, and the support works at an almost unbelievable speed.

I have been using Nettle for about a year now, and I can truly say it has helped me — a lot — to live a much better quality of life. I have suffered from very painful periods my entire life, and about seven years ago severe PMS symptoms were added to that — intense irritability, emotional overwhelm, and yes, an unstoppable craving for chocolate. I understood that it was PMS, but I had absolutely no tools to work with my emotions.

On top of that, during PMS I was often unable to work for around 7–10 days each month. Then my period itself would last about 5 days, and suddenly I realized that in a 27-day cycle I only had about one “normal” week. This had a huge impact on both my work and overall quality of life.

When I discovered Emilie and learned that she was creating something new, I was one of the very first people to try Nettle. Since then, my PMS has improved dramatically. I no longer feel uncontrollably angry or emotionally overwhelmed, and most importantly — I am functional, productive, and have energy. The menstrual pain that used to be unbearable has significantly decreased. I still take pain medication because the pain is not completely gone, but now it is manageable and the medication works within 15–20 minutes. Before, it often didn’t work at all, leaving me in pain with no options left.

I truly and wholeheartedly recommend this device, because it has genuinely helped me.

I did experience some challenges with the device itself — it sometimes charged very slowly and occasionally wouldn’t charge at all. Eventually, one day it stopped charging completely and appeared to malfunction. However, the support team reacted immediately and wonderfully, and a replacement Nettle is already on its way to me. This level of care and responsibility only strengthens my trust in the brand.

Nettle is a revolutionary device for taking back the responsabilitues of our health. It s wonderfull to manage ans schedule a session with nettle the moment u need it.
It is very efficient because we can act daily on our pain and discomfort.